Exciting mechanism
Novel nasal formulation of relaxin, activating GR and RXFP1 with protective effects.
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Neuvene™ (Lynflexine™), is a first-in-class drug candidate with disease modifying potential for the treatment of relapsing remitting and progressive forms of multiple sclerosis and for the treatment of neurodegeneration following concussion.
Multiple sclerosis (MS) is an autoimmune disease affecting principally the central nervous system that causes nerve sheath demyelination followed by axon damage and paralysis. MS symptoms include muscle weakness, weak reflexes, tremor, muscle spasm, prolonged double vision, slurred speech, and lack of coordination or unsteady gait. MS can occur at any age, but commonly affects people of ages 15–60 years. MS symptoms may occur and disappear completely, while the permanent neurological problems occur when the disease advances (Mayo Clinic, 2019).
The diagnosis of MS depends upon the patient symptoms, magnetic resonance imaging (MRI), and laboratory results, but it is mostly diagnosed in the late phases. Presently, MS is diagnosed by the widely used McDonald criteria, which is a combination of laboratory, clinical, and radiology reports of lesions at different times in different body areas (Lublin, 2014). Currently, there is no cure for MS. However, treatments can help speed recovery from attacks, modify the course of the disease, and manage symptoms (Mayo Clinic, 2019).
Exciting mechanism
Novel nasal formulation of relaxin, activating GR and RXFP1 with protective effects.
A natural hormone
A human hormone, potential as a treatment for MS underpinned by scientific rationale.
First-in-Class
An new and unique mechanism of action to treat multiple sclerosis
Low Risk
Relaxin's targets are known and the molecule is naturally occurring in the body.
Excellent safety
Because the molecule is a human hormone, it is expected to have an excellent safety profile.
Ample evidence
The preclinical results are supported by the known improvement in MS patients during pregnancy.
in development targeting Multiple Sclerosis, and other CNS indications. It has the potential to modulate the clinical symptoms of MS, be neuroprotective and promote remyelination.
The potential of Neuvene to remyelinate nerves and restore function creates a paradigm shift in our approach to MS and other neurodegenerative disorders.
Dr Roy Garvin, CEO, BVBiomedical Ltd
Our aim is to meet the challenge of neurodegenerative diseases such as multiple sclerosis and traumatic encephalopathy with transforming nose-to-brain delivery technologies able to unlock the potential of relaxin.
Dr Aikaterini Lalatsa, Reader - Deputy Director CRUK Formulation Unit, School of Pharmacy and Biomedical Science, University of Strathclyde
Re:Cognition Health is excited about the opportunity to work with BVbiomed and their new therapeutic compound “relaxin”, intended for the treatment of neurodegenerative diseases. This new “first in class” medication crosses and stabilises the blood brain barrier and can be delivered as a nasal spray. In the elusive search for an intervention to potentially prevent and treat CTE, this could be a solution and change the future for millions of contact sports players.
Dr J Emer MacSweeney, Co-Founder & CEO Re:Cognition Health
Neuvene™ is expected to be a safe and effective treatment in a convenient nasal spray formulation. It is being developed as a therapy for acute attacks in multiple sclerosis; relapsing remitting and chronic forms of multiple sclerosis; neurodegeneration caused by concussion and/or traumatic brain injury.
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